Entecavir Hydrate

- Overview
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    Background
    
    Entecavir hydrate is a reverse transcriptase inhibitor.Reverse transcriptase (RT) is used to generate complementary DNA (cDNA) from an RNA template, which is mainly associated with retroviruses, such as HBV. Entecavir hydrate is an oral antiviral drug used in the treatment of hepatitis B virus (HBV) infection. In 17 patients with hepatitis B virus (HBV) genotype C, treatment with peginterferon(PEG-IFN) a-2b combination with entecavir hydrate (ETV) for 48 weeks. Among 11 patients exhibited pretherapy HBeAg, 8 showed HBeAg seroconversion. Serum HBV DNA levels reduced by 5.2 and 3.3 log copies/ml by the end of the therapy and follow-up periods, respectively. Intrahepatic cccDNA reduced to 1.4 log copies/mg.
    
    [1]. Hagiwara S, Kudo M, Osaki Y, et al. Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B. J Med Virol, 2013, 85(6): 987-995.
- Properties
  - Categories
    
    Antiviral drug used in hepatitis B infection
    
    Alternative Name
    
    2-amino-9-[(3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one;hydrate
    
    CAS Number
    
    209216-23-9
    
    Molecular Formula
    
    C12H15N5O3·H2O
    
    Molecular Weight
    
    295.29
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥9.7 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C=C1C(CC(C1CO)O)N2C=NC3=C2NC(=NC3=O)N.O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

Entecavir Hydrate

Background

Documents

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