Name: Venturicidin B
Price: 421.00 USD

- Overview
  - Venturicidin B (Aabomycin A2) is a 20-member macrolide glycoside compound that was originally isolated from a Streptomyces sp.by Glaxo Labs in 1961. Venturicidin B is a potent antifungal and toxic antibiotic compound, that has also shown cytotoxicity to trypanosomes.
    Venturicidin B is a potent inhibitor of bacterial and mitochondrial ATP-synthase complexes acting on the F0 membrane sector, with experiments suggesting that the compound strongly inhibits ATP-driven proton transport and ATP hydrolysis. Venturicidin B demonstrates the ability to drastically decrease the open probability of voltage sensitive K+ channels. Venturicidin B is an inhibitor of ATP5 as well as a potential inhibitor of E. coli H+-ATPase.
    Venturicidin B is soluble in ethanol, methanol, DMF and DMSO.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Venturicidin B binds to the subunit-c of the coupling factor o, or Fo of mitochondrial and bacterial ATP synthase complex. Once bound to the ATP synthase, Venturicidin B blocks proton translocation and inhibits ATP synthesis in both fungi and bacteria.
- Properties
  - CAS Number
    
    33538-72-6
    
    Molecular Formula
    
    C40H66O10
    
    Molecular Weight
    
    707.0
    
    Appearance
    
    White Lyophilisate
    
    Other Properties
    
    Source: Streptomyces sp.
    Identification: Positive
    Purity Level: >95% by HPLC
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Venturicidin B is potent inhibitor of fungal and bacterial strains and has low toxicity for higher plants and animals.
    
    Plant Biology Applications: Venturicidin protects plants from infection with pathogenic fungi such as Erysiphe graminis, Erysiphe cichoracearum, Podoshpaera leucotricha and Botrytis cinerea. It is also effective against fungi in the genus Venturia which can cause apple scab.