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Overview
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Leptomycin B is the dominant member of the Leptomycin class, secondary metabolites isolated from selected Streptomyces strains. It is a bioactive small molecule with antifungal and antibacterial activity. It is a nuclear export inhibitor, targeting chromosome region maintenance 1 (CRM1), a nuclear export receptor and a protein in the nuclear export signal (NES) thus can be used as a tool to study nuclear export. Leptomycin B is an inhibitor of nucleo-cytoplasmic translocation of HIV-1 Rev protein and Rev-dependent mRNA. It has anti-cancer activity and can modulate cancer-specific pathways.
Leptomycin B is soluble in ethanol and methanol, practically insoluble in water, and unstable in DMSO.Please contact us at for specific academic pricing.
Background
Leptomycin B is a highly specific and potent inhibitor of CRM1 function. It binds irreversibly with the sulfhydryl group of a Cys residue in the cargo biding domaine of CRM1. It affects proteins c-Abl, cyclin B1, HIV-1 Rev, IκB, MPF, MAP/ERK, MDM2/p53, NF-κB/IκB7 and PKA. Leptomycin B inhibits the export of many RNAs (COX-2, cFOS mRNA).
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- Properties
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Overview