Venturicidin A

Venturicidin A (Aabomycin A1) is a 20-member macrolide glycoside compound that was first isolated from a Streptomyces sp. by Glaxo Labs in 1961. Venturicidin A is a potent antifungal and toxic antibiotic compound, that has also shown cytotoxicity (IC50 = 120-540 ng/ml) to trypanosomes.

Venturicidin A is a potent inhibitor of bacterial and mitochondrial ATP-synthase complexes acting on the F0 membrane sector, with experiments suggesting that the compound strongly inhibits ATP-driven proton transport and ATP hydrolysis. Venturicidin A demonstrates the ability to drastically decrease the open probability of voltage sensitive K+ channels. Venturicidin A is an inhibitor of ATP5 as well as a potential inhibitor of E. coli H+-ATPase.
Venturicidin A is soluble in ethanol, methanol, DMF and DMSO.

Please contact us at for specific academic pricing.

Background

Venturicidin A binds to the subunit-c of the coupling factor o (Fo) of mitochondrial and bacterial ATP synthase complexes. Once bound to the ATP synthase complex, Venturicidin A blocks proton translocation and inhibits ATP synthesis in both fungi and bacteria.