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Overview
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Vancomycin is a glycopeptide antibiotic derived from Streptomyces orientalis that was discovered in 1953 from a soil sample found in Borneo. It is effective against gram-positive bacteria such as Staphylococcus aureus and is used in studies of nanoparticle transport and antibiotic resistance studies.
Vancomycin acts as a cell wall synthesis inhibitor in bacteria by preventing the transfer and addition of NAM/NAG-peptides that make up the peptidoglycan cell wall structure.
Vancomycin has low cell toxicity in plant cells and has been used in conjunction with Cefotaxime or Carbenicillin to stop the growth of Agrobacterium in plant cell culture and transformation.Please contact us at for specific academic pricing.
Background
Vancomycin prevents cell wall synthesis by two separate mechanisms. One mechanism prevents N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) peptides from linking together forming the peptidoglycan backbone through the incorporation of the Vancomycin molecule to the D-alanyl-D-alanine terminal. The second mechanism prevents crosslinking between amino acid residues in the peptidoglycan chain altering bacterial cell membrane permeability as well as RNA synthesis.
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- Properties
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Overview