Valrubicin

- Overview
  - Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. It is used for cancer research in models of bladder cancer.
    
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    Background
    
    Valrubicin is converted into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, an enzyme that relaxes DNA supercoils. DNA replication and repair is inhibited, which prevents RNA synthesis and protein production, resulting in cell cycle arrest in phase G2. Valrubicin also accumulates in the cytoplasm where it inhibits protein kinase C.
- Properties
  - CAS Number
    
    56124-62-0
    
    Molecular Formula
    
    C34H36F3NO13
    
    Molecular Weight
    
    723.65
    
    Appearance
    
    Orange to orange red crystalline powder
    
    Other Properties
    
    Source: Semi-synthetic
    Purity Level: 98-102% (dried basis)
    
    Storage
    
    ≤30°C (avoid light)
    
    * For research use only