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UbE3A (E6AP)

UbE3A (E6AP)

Catalog Number:

EUL1097364UBP

Mfr. No.:

K1411

Price:

$424

Size:

50 µg

Quantity:

Add to Cart:

- Overview
  - UbE3A (also called E6AP) is a 100 kDa HECT (homologous to E6AP carboxyl terminus) domain ubiquitin ligase containing two E2 binding sites for UbcH7 and UbcH8. UbE3A was found to bind to the human papillomavirus (HPV) oncoprotein E6 and mediate ubiquitination of p53. A frameshift mutation in the UbE3A gene leads to loss of function and causes Angelman Syndrome.
    
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- Properties
  - Protein Name
    
    AS; ANCR; E6-AP; E6AP; HPVE6A; EPVE6AP
    
    Source
    
    Bacterial recombinant
    
    Formulation
    
    20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
    
    Storage
    
    Store at -80°C; avoid multiple freeze-thaw cycles
    
    Concentration
    
    See tube label
    
    Molecular Weight
    
    100.7 kDa
    
    Sequence
    
    NCBI RefSeq: NM_000462.3
    
    * Research Use Only

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