TPO, human recombinant protein

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Background

Thrombopoietin (TPO), also known as megakaryocyte growth and development factor (MGDF), is a membrane-bound glycoprotein produced in the liver, kidney and skeletal muscle. TPO plays important roles in megakaryocytopoiesis and thrombopoiesis. TPO stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor.
The human TPO gene encodes a 353 aa protein contains a 21 aa signal sequence, a 15 amino acid erythropoietin-like domain, and a highly glycosylated 179 amino acid C-terminal domain. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.