SDF-1beta (CXCL12), human recombinant

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Background

Human stromal cell-derived factor-1β (SDF-1β) is a member of the CXCL chemokine family that signals through the CXCR4 receptor. CXCL12 is strongly chemotactic for lymphocytes and induce migration of CD34+ stem cells. In cells expressing the CXCR4 receptor, CXCL12 exerts HIV-suppressive activity.
The mature SDF-1β protein is the product of alternative splicing of the SDF-1 gene and contains 72 amino acid residues. Human and murine SDF-1 proteins act across species. Recombinant human SDF-1β is an 8.5 kDa protein containing 72 amino acid residues.