Name: TNIIIA2
Price: 314.00 USD

- Overview
  - ?1 integrin activator
    TNIIIA2 is a peptide derived from the matricellular protein tenascin-C, a protein which is highly expressed in inflammatory bowel diseases including colorectal cancer, where tenascin-C expression level is correlated with poor prognosis. TNIIIA2 induces potent and sustained activation of ?1 integrin and promotes invasion and metastasis in colon cancer cells, and causes acquisition of aggressive behaviour, dysregulated proliferation, and migration in glioblastoma cells. In an osteoarthritis mouse model, TNIIIA2 upregulates the expression of tumour necrosis factor-Î±, matrix metalloproteinase 3, and basic fibroblast growth factor and prevents articular cartilage degeneration without inducing synovitis.
    
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- Properties
  - Categories
    
    Peptides
    
    Molecular Formula
    
    C103H173N31O31
    
    Molecular Weight
    
    2373.73
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in saline
    
    Other Properties
    
    Sequence: H-Arg-Ser-Thr-Asp-Leu-Pro-Gly-Leu-Lys-Ala-Ala-Thr-His-Tyr-Thr-Ile-Thr-Ile-Arg-Gly-Val-Cys-OH,RSTDLPGLKAATHYTITIRGVC
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

TNIIIA2

TNIIIA2

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