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Overview
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Background
TG100801 is a multi-kinases inhibitor. It is a pro-drug version of TG100572. [1]
TG100572 inhibits several growth factor receptors in addition to Src family kinases. TG100801 significantly inhibited laser-induced CNV in mice, and suppressed fluorescein leakage from the vasculature and retinal thickening measured by optical coherence tomography in a rat model or retinal vein occlusion. TG100801 may play as a new topically applied treatment approach for ocular neovascularization and retinal edema. The highest concentration of TG100801 was found at the front of the rat eye (conjunctiva and cornea). [1]
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