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TFLLR-NH2

TFLLR-NH2

Catalog Number:
P004516938LIF
Mfr. No.:
PEPTIDE-PR-040
Price:
$212
  • Size:
    1mg
    Quantity:
    Add to Cart:
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      • Overview

        • PAR1 selective agonist.
          TFLLR-NH2 is a peptide derived from the protease activated receptor 1 (PAR1) that acts as a PAR1 selective agonist, with an EC50 of 1.9 μM. TFLLR-NH2 is widely used to activate platelets and has also been shown to elicit scratching in mice. Platelet activation of SW620 colon cancer cells with TFLLR-NH2 triggers TGF-? secretion, which induces epithelial-mesenchymal transition (EMT) through the downregulation of miR-200b expression. Activated platelets have a chemotactic effect on colon cancer cells mediated by the upregulation of CXCR4 on the cell surface.

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          Please contact us at for specific academic pricing.

      • Properties
        • Categories
          Peptides
          Alternative Name
          PAR1-AP
          Molecular Formula
          C31H53N9O6
          Molecular Weight
          647.82
          Appearance
          Freeze dried solid
          Purity
          >95% by HPLC
          Solubility
          Soluble to 1 mg/ml in water
          Other Properties
          Sequence: Thr-Phe-Leu-Leu-Arg-NH2,TFLLR-NH2
          Modification: C-terminal amide
          Storage
          Store dry, frozen and in the dark

          * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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