Temocillin Disodium

- Overview
  - Temocillin Disodium is the salt of Temocillin, a semisynthetic, β-lactamase-resistant carboxypenicillin antimicrobial. Temocillin is the 6-alpha-methoxy derivative of ticarcillin. Temocillin is is used as an alternative to carbapenems and is primarily effective against Gram-negative bacteria. Temocillin Disodium is soluble in water.
    
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    Background
    
    Like other β-lactams, Temocillin Disodium interferes with penicillin binding protein (PBP) activity involved in the final phase of peptidoglycan synthesis. PBB catalyzes the pentaglycine crosslink between alanine and lysine. Without a pentaglycine crosslink, the integrity of the cell wall is compromised which leads to cell lysis and death. Temocillin is resistant to most β-lactamases, but resistance is commonly due to cells containing plasmid-encoded β-lactamases.
- Properties
  - CAS Number
    
    61545-06-0
    
    Molecular Formula
    
    C16H18N2Na2O7S2
    
    Molecular Weight
    
    458.42
    
    Appearance
    
    White or almost white powder
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Source: Semi-synthetic
    Purity Level: ≥90.00%
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Temocillin is active against several multi-resistant Gram-negative species including Salmonella typhimurium, E. coli, Haemophilus influenzae and others. In contrast, Gram-positive bacteria, bacteria with altered penicillin-binding proteins, and Pseudomonas aeruginosa are not susceptible to temocillin.
    
    Microbiology Applications: Temocillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-negative microbial isolates. Medical microbiologists use this information to recommend antibiotic treatment options. Representative MIC ranges include:
    
    E. coli 1.00 µg/mL - 64.00 µg/mL
    H. influenzae β-lactamase negative: 0.25 - 0.50 µg/ml
    H. influenzae β-lactamase positive: 0.50 - 1.00 µg/ml
    S. aureus >128.00 µg/ml