Teicoplanin A2-5

- Overview
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    Background
    
    Teicoplanin A2-5, derived from Actinoplanes teichomyceticus, is a glycopeptide antibiotic which produces a broad spectrum of antibiotic activity against gram-positive bacteria. Teicoplanin A2-5 is the most non-polar metabolite in the family of teicoplanins. Teicoplanin, previously referred to in the literature as teichomycin, is a mixture of five closely related components of similar polarity, designated T-A2-1, 2, 3, 4 and 5 and of one more polar component, designated T-A3. Additionally, as a glycopeptide antibiotic belonging to the same family as vancomycin, teicoplanin blocks cell wall synthesis in Bacillus subtilis, which is accompanied by an intracellular accumulation of UDP-N-acetylmuramyl-pentapetide [1]. Due to the greater antibacterial activity of teicoplanin than other agents, it has been thoroughly studied as a β-1actamase-resistant agent for the treatment of human infections caused by streptococci and staphylococci, including enterococci [2].In vitro: Up to now, in vitro study of Teicoplanin A2-5 is still in the development stage.In vivo: Up to now, in vivo study of Teicoplanin A2-5 is still in the development stage.
    
    [1]. Somma, S., Gastaldo, L., & Corti, A. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. Antimicrobial Agents and Chemotherapy. 1984; 26(6): 917-923.
    [2]. Traina, G., & Bonati, M. Pharmacokinetics of teicoplanin in man after intravenous administration. Journal of Pharmacokinetics and Biopharmaceutics. 1984;12(2): 119-128.
- Properties
  - Categories
    
    glycopeptide antibiotic
    
    Alternative Name
    
    34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(9-methyl-1-oxodecyl)amino]-β-D-glucopyranosyl]-42-O-α-D-mannopyranosyl-ristomycin A aglycone
    
    CAS Number
    
    91032-38-1
    
    Molecular Formula
    
    C89H99Cl2N9O33
    
    Molecular Weight
    
    1893.7
    
    Appearance
    
    A lyophilisate
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(CCCCCCC/C(O)=N/[[email protected]]([[email protected]@](OC1=C2C=C([[email protected]](/N=C(O)\[[email protected]](/N=C(O)/[[email protected]@](/N=C(O)\[[email protected]@](N)([H])C3=CC4=C(O)C=C3)([H])CC5=CC(Cl)=C(O2)C=C5)([H])C6=CC(O)=CC(O4)=C6)([H])/C(O)=N/[[email protected]](/C(O)=N/7)([H])C8=CC(C9=C([[email protected]@]%10([H])C(O)=O)C=C(O)C=C9O[[email protected]]%11([H])[[email protected]](O)([H
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Teicoplanin A2-5

Background

Documents

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