Teicoplanin A2-3

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Teicoplanin A2-3 is a major component of the teicoplanin complex [1-3]. Teicoplanins, lipoglycopeptide antibiotics, are glycopeptide antibiotics produced by A. teichomyceticus that are broadly effective against Gram-positive bacteria in vitro. Teicoplanins consist of five major components (A2-1, A2-2, A2-3, A2-4 and A2-5), one hydrolysis component (A3-1), and four minor components (RS-1, RS-2, RS-3, RS-4) [1]. Teicoplanins have been recently used for the treatment of multitudinous aerobic and anaerobic Gram-positive infections. Teicoplanins have been rapidly and extensively absorbed from the peritoneal cavity and muscle, but very poorly absorbed from the gastrointestinal tract [2]. Teicoplanin is highly bound in plasma to albumin and in tissues. Both renal and nonrenal mechanisms have been implicated in the elimination of the drug. For at least after one day administration, the concentrations of teicoplanin in serum and urine exceeded the MIC ranging from 0.02-2 μg/ml on many pathogenic organisms [3].
    
    [1] Bernareggi A, Borghi A, Borgonovi M, et al. Teicoplanin metabolism in humans[J]. Antimicrobial agents and chemotherapy, 1992, 36(8): 1744-1749.
    [2] Rowland M. Clinical pharmacokinetics of teicoplanin[J]. Clinical pharmacokinetics, 1990, 18(3): 184-209.
    [3] Traina G L, Bonati M. Pharmacokinetics of teicoplanin in man after intravenous administration[J]. Journal of Pharmacokinetics and Pharmacodynamics, 1984, 12(2): 119-128.
- Properties
  - Categories
    
    glycopeptide antibiotic
    
    Alternative Name
    
    34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(1-oxodecyl)amino]-β-D-glucopyranosyl]-42-O-α-D-mannopyranosyl-ristomycin A aglycone
    
    CAS Number
    
    91032-36-9
    
    Molecular Formula
    
    C88H97Cl2N9O33
    
    Molecular Weight
    
    1879.7
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCCCCCCCC/C(O)=N/[[email protected]]([[email protected]@](OC1=C2C=C([[email protected]](/N=C(O)\[[email protected]](/N=C(O)/[[email protected]@](/N=C(O)\[[email protected]@](N)([H])C3=CC4=C(O)C=C3)([H])CC5=CC(Cl)=C(O2)C=C5)([H])C6=CC(O)=CC(O4)=C6)([H])/C(O)=N/[[email protected]](/C(O)=N/7)([H])C8=CC(C9=C([[email protected]@]%10([H])C(O)=O)C=C(O)C=C9O[[email protected]]%11([H])[[email protected]](O)([H]
    
    * For Research Use Only