TCS 2002

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    TCS 2002 is a potent inhibitor of GSK-3β with IC50 value of 35 nM [1]. Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase and functions by phosphorylating a serine or threonine residue on its target protein. GSK3β plays an important role in neuronal cell development, energy metabolism and body pattern formation. TCS 2002 is a potent GSK -3β inhibitor with IC50 value of 35 nM. (S) -TCS 2002 and (R) -TCS 2002 inhibited GSK-3β with IC50 values of 34 and 140 nM, respectively. TCS 2002 exhibited good bioavailability (F=40%) and solubility (38 μg/mL). (S) -TCS 2002 showed no inhibitory activity against 12 tyrosine kinases and 10 serine/threonine kinases up to 10 μM, indicating that (S) -TCS 2002 was a highly selective GSK -3β inhibitor [1]. In mice, cold water stress (CWS) induced tau hyperphosphorylation at several GSK -3β directed sites such as S199, Thr205, Thr231 and Ser396. (S) -TCS 2002 significantly inhibited tau phosphorylation by 35% [1].
- Properties
  - Alternative Name
    
    2-methyl-5-(3-(4-(methylsulfinyl)phenyl)benzofuran-5-yl)-1,3,4-oxadiazole
    
    CAS Number
    
    1005201-24-0
    
    Molecular Formula
    
    C18H14N2O3S
    
    Molecular Weight
    
    338.38
    
    Appearance
    
    White solid
    
    Purity
    
    98.00%
    
    Solubility
    
    <33.84mg/ml in DMSO; <8.46mg/ml in ethanol
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

TCS 2002

Background

We Also Recommend

BIO-acetoxime

EHT 1864

Kisspeptin 234