Name: TAT-QFNP12
Price: Inquiry

- Overview
  - NDRG2 – PPM1A binding blocker.
    TAT-QFNP12 is a peptide corresponding to the 302 to 313 amino acid domain of the protein phosphatase PPM1A, made cell permeable by the addition of TAT, and is a key fragment involved in the binding of PPM1A to the cytoplasmic protein NDRG2. TAT-QFNP12 blockade of the binding of NDRG2 with PPM1A allows PPM1A to enter the nucleus and dephosphorylate Smad2/3, preventing transcription and production of matrix metalloproteinase 9 (MMP-9). Unwanted increased levels of MMP-9 have an important part in blood-brain barrier (BBB) injury in subarachnoid haemorrhage (SAH) and can critically exacerbate poor prognosis. In mouse models of SAH, TAT-QFNP12 dose-dependently inhibits MMP-9 expression and Smad2/3 phosphorylation, and significantly reduces brain edema and neurological deficits, demonstrating that TAT-QFNP12 can protect the blood-brain barrier after SAH and alleviate secondary nerve injury.
    
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- Properties
  - Categories
    
    Cell Penetrating Peptides
    
    Molecular Formula
    
    C130H225N47O35
    
    Molecular Weight
    
    3004.73
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Val-Lys-Lys-Glu-Ala-Glu-Leu-Asp-Lys-Tyr-Leu-Glu-OH,YGRKKRRQRRRVKKEAELDKYLE
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

TAT-QFNP12

TAT-QFNP12

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