Sphericalplate 5D

- Overview
  - Sphericalplate 5D (SP5D) platform technology allows the creation of highly standardised cell spheroids, freely scalable from hundreds for the laboratory to millions for clinical use. Aiming to fulfill highest medical and regulatory standards, seamless translation into diagnostic or clinical use is enabled.
    Standardized, uniform, size controlled spheroids in large scale. 750 cell clusters with one move – 9000 per plate.
    
    OUR TECHNOLOGY
    • Uniformely sized spheroids
    • Physiological, standardized and easy spheroid formation by optimized niche geometry and surface
    • Convenient upscaling without loss of spheroid quality
    • Ability to translate into diagnostic or clinical use
    
    SAFETY FIRST
    • Effortless upscaling of your cell spheroids without losing control over cell differentiation and spheroid size
    • Medium change in your culture is rather simple and can be automated as well
    • The safety profile of the SP5D reduces the risk of unintended tumorigenesis to a minimum which is a prerequisite for all translational approaches
    
    SIZE AND SPACE MATTERS
    Due to our patented geometry:
    • Precise control of spheroid size resulting in higher standardization & reproducibility
    • High quantity of uniformly sized spheroids (9000/plate)
    • Identical diffusion conditions for all spheroids
    • Unique physiological spheroid formation with rounded bottoms
    
    BENEFITS AT A GLANCE
    
    Please contact us at for specific academic pricing.
    
    More Details
    
    Sphericalplate 5D
    
    3D Cell Culture
- Properties
  - Categories
    
    24-multiwell plate for 3D cell culture
    
    * Currently the SP5D is for research use only.
- Applications
  - Application Description
    
    The Sphericalplate 5D allows the generation of uniform, size-controlled cell clusters needed for various reasearch and diagnostic applications. Our platform enables the translation from bench to bedside and includes scalable, reliable and safe application of cell therapy. The SP5D has round-bottomed microwells and the surface is covered with high-end ultra-low attachment coating which allows for perfect cell aggregation. 3D cell culture protocols using the SP5D are highly scalable, as one plate can hold up 9000 spheroids. The scalable solutions on the market do not meet the required quality criteria for safe clinical use, therefore our SP5D closes this gap.
- Reference
  - Hypoxia Onset in Mesenchymal Stem Cell Spheroids: Monitoring With Hypoxia Reporter Cells Engineering of Primary Pancreatic Islet Cell Spheroids for Three-dimensional Culture or Transplantation: A Methodological Comparative Study Automation, Monitoring, and Standardization of Cell Product Manufacturing SV40 Transfected Human Anterior Cruciate Ligament Derived Ligamentocytes-Suitable as a Human in Vitro Model for Ligament Reconstruction? 3D Cardiac Cell Culture: A Critical Review of Current Technologies and Applications Gaining Insights into the Function of Post-Translational Protein Modification Using Genome Engineering and Molecular Cell Biology Nano-synergistic combination of Erlotinib and Quinacrine for non-small cell lung cancer (NSCLC) therapeutics – Evaluation in biologically relevant in-vitro models