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Overview
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A hyper acid-labile linker or the Fmoc SPPS of protected amides via mild 1% TFA cleavage. The resin can be readily reductively alkylated to provide a support suited to the synthesis of secondary carboxamides. This resin has also been employed to produce protected peptide fragments in wich the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester.
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Overview
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