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Overview
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Siccanin is an unusual fused phenolic pentacycle first isolated from Helminthosporium siccans reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the Siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by Siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.
Siccanin is soluble in ethanol, methanol, DMF and DMSO.Please contact us at for specific academic pricing.
Background
Siccanin inhibits succinate dehydrogenase in the terminal electron transport system.
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- Properties
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Overview