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Overview
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Securinine is a tetracyclic alkaloid isolated from the roots of Securinega suffruticosa with an unusual structure in which the piperidine ring has a skewed boat form and the diene is not coplanar. Securinine inhibits [3H]GABA binding to rat brain membranes with an IC50 of approximately 50 µM. Securinine induces toll-like receptor (TLR)-independent macrophage activation in vitro, leading to IL-8 secretion, L-selectin down-regulation, and CD11b and MHC Class II antigen up-regulation. Securinine is an active antitumor agent, inducing p73-dependent apoptosis preferentially in p53-deficient colon cancer cells and inhibits the cell migration/invasion ability of DU145 prostate cancer cells.
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