Ciprofloxacin

85721-33-1

C17H18FN3O3

331.34 g/mol

White or light yellow crystalline powder

Sparingly soluble in aqueous solution (1.1 µg/ml)

Source: Synthetic
Assay: 98.0% - 102.0%
Residue On Ignition: ≤0.1%
Heavy Metals: ≤20ppm
Loss on Drying: ≤1.0%
Identification: HPLC, IR

2-8 °C; protect from light

Spectrum: Ciprofloxacin is a broad-spectrum antibiotic targeting a wide variety of Gram-positive and Gram-negative bacteria. It is also effective against Mycoplasmas.

Microbiology Applications: Ciprofloxacin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Plant Biology Applications: Garlic protoplasts were cultured in medium containing Ciprofloxacin, and the compound was successful at preventing microbial growth and was not toxic to the protoplasts (Fellner, 1995).

Cancer Applications: Two transitional cell carcinoma cell lines, MBT‐2 and T24, were used in an in vitro study of the effects of Ciprofloxacin on cell proliferation, and the compound was found to inhibit cell proliferation in a dose-dependent manner (Ebisuno et al, 1997). When cells become malignant, they often lose their primary cilium, a microtubule-based sensory organelle. Thus, the potential to restore the cilium is being investigated as a therapeutic approach to attenuate tumor growth in cancer research. Commonly used chemotherapeutic drugs like Cefprozil can restore ciliogenesis, and thus they are referred to as ciliogenic drugs. Using pancreatic cancer cell lines CFPAC-1 and PANC-1, researchers found a causative link between secreted ATP and cilia induction via an autocrine/paracrine loop involving extracellular ATP-purinergic receptor signaling pathway (Khan et al, 2017).