BAFF, human recombinant protein

Please contact us at for specific academic pricing.

Background

Human B cell activating factor (BAFF) is a 32 kDa transmembrane glycoprotein produced by T cells, macrophages, monocytes and dendritic cells. BAFF is a member of the TNF family of ligands and is involved in stimulation of B and T cell function. BAFF plays important roles in survival and maturation of peripheral B cells. BAFF signals through three different TNF receptors: TACI, BCMA and BAFF-R.
The human BAFF gene codes a 285 aa transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant human BAFF is a soluble protein containing 153 amino acid residues with a N-terminal His-tag (MW 19.335 kDa)