Name: SAP15
Price: 298.00 USD

- Overview
  - HDAC5 inhibitor.
    SAP15 is a cell penetrating peptide corresponding to the last 15 amino acids of the host defense peptide human ?-defensin 3, which is involved in adaptive immunity and pro- and anti-inflammatory responses. SAP15 is a histone deacetylase 5 (HDAC5) inhibitor with a dissociation constant of 86 nM in an SPR assay and inhibits lipopolysaccharide (LPS) induced phosphorylation of intracellular HDAC5 and NF-κB p65 in murine macrophages. In vivo, subcutaneous injection of SAP15-loaded sodium hyaluronic acid solution significantly decreases hind paw swelling, joint inflammation, and serum cytokine levels in a collagen induced arthritis (CIA) rat model.
    
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- Properties
  - Categories
    
    Antimicrobial Peptides
    
    Alternative Name
    
    Peptide 3
    
    Molecular Formula
    
    C68 H131N31O18S3
    
    Molecular Weight
    
    1767.18
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Gly-Lys-Cys-Ser-Thr-Arg-Gly-Arg-Lys-Cys-Cys-Arg-Arg-Lys-Lys-OH,GKCSTRGRKCCRRKK
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

SAP15

SAP15

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