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RS 504393

RS 504393

Catalog Number:
L002368850APE
Mfr. No.:
APE-A3779
Price:
$326
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      • Overview

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          Background

          RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). RS 504393 inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.

      • Properties
        • Categories
          CCR2 chemokine receptor antagonist
          Alternative Name
          RS-504393; RS504393; 6-methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
          CAS Number
          300816-15-3
          Molecular Formula
          C25H27N3O3
          Molecular Weight
          417.5
          Appearance
          A solid
          Purity
          98.00%
          Solubility
          ≥8.28 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
          Storage
          Store at -20°C
          SMILES
          CC1=CC2=C(NC(OC23CCN(CCC4=C(C)OC(C5=CC=CC=C5)=N4)CC3)=O)C=C1

          * For Research Use Only

      • Reference

        • 1. Jinghua Jiang , Fei Ye, et al. "Peri-tumor associated fibroblasts promote intrahepatic metastasis of hepatocellular carcinoma by recruiting cancer stem cells." Cancer Letters.17 July 2017 1/10.

    Documents

    COA (Certificate Of Analysis)

    MSDS (Material Safety Data Sheet)

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