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RS 504393

RS 504393

Catalog Number:

L002368850APE

Mfr. No.:

APE-A3779

Price:

$326

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- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    RS 504393 is a selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). RS 504393 inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.
- Properties
  - Categories
    
    CCR2 chemokine receptor antagonist
    
    Alternative Name
    
    RS-504393; RS504393; 6-methyl-1'-(2-(5-methyl-2-phenyloxazol-4-yl)ethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
    
    CAS Number
    
    300816-15-3
    
    Molecular Formula
    
    C25H27N3O3
    
    Molecular Weight
    
    417.5
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥8.28 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1=CC2=C(NC(OC23CCN(CCC4=C(C)OC(C5=CC=CC=C5)=N4)CC3)=O)C=C1
    
    * For Research Use Only
- Reference
  - 1. Jinghua Jiang , Fei Ye, et al. "Peri-tumor associated fibroblasts promote intrahepatic metastasis of hepatocellular carcinoma by recruiting cancer stem cells." Cancer Letters.17 July 2017 1/10.

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

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