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Overview
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Background
Retinyl glucoside is a lipid glucoside and metabolite of Vitamin A [2] [3]. Glycosylation of vitamins exert various nutritional and metabolic effects [1].As a product of in vitro enzymatic glycosylation, retinyl glucoside was hydrolyzed by two mammalian broad specificity β-glucosidases, the cytosolic and membrane-associated β-glucosidases of guinea pig liver [1] [2].In vitamin A-deficient rats, retinyl β-glucose exhibited 67-100% of the growth-promoting, and was quickly hydrolyzed to retinol in metabolic studies [3].
1. Gregory JF 3rd. Nutritional Properties and significance of vitamin glycosides. Annu Rev Nutr. 1998;18:277-96. Review. PubMed PMID: 9786648.
2. Vanderjagt DJ, Fry DE, Glew RH. Human glucocerebrosidase catalyses transglucosylation between glucocerebroside and retinol. Biochem J. 1994 Jun1;300 ( Pt 2):309-15. PubMed PMID: 8002933; PubMed Central PMCID: PMC1138163.
3. Barua AB, Olson JA. Chemical synthesis, growth-promoting activity, and metabolism of all-trans retinyl beta-glucose in the rat. Int J Vitam Nutr Res. 1992;62(4):298-302. PubMed PMID: 1291531.
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