Name: Reversine
Price: 215.00 USD

- Overview
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    Background
    
    IC50: 150, 500 and 400 nM for Aurora Kinase A, B and C respectivelyReversine is a novel Aurora kinases inhibitor. Aurora kinases are serine/threonine kinases playing a key role in mitotic regulation. Aurora A kinase resides at spindle poles during mitosis and is implicated in the control of centrosome maturation, duplication, and separation. Aurora B is part of a chromosome passenger complex and is implicated directly in the control of microtubule kinetochore attachment. Aurora kinases have emerged as valuable targets in cancer therapy.In vitro: Reversine could be used to induce dedifferentiation of murine myoblasts. Previous reports also showed that reversine had a role in regeneration. Moreover, a recent report indicated reversine had anti-tumor capabilities for a myeloma cell line, as demonstrated by that reversine could suppress the expression of cell cycle related proteins Aurora kinase A and Aurora kinase B [1]. In vivo: The effects of reversine on tumor weight and volume were assessed using a murine model of cervical cancer with U14 cells, separately or combined with aspirin. The inhibition rate of cells in the combination group significantly increased; moreover, such combination could synergistically inhibit the proliferation of five cervical cancer cell lines. In the mouse model, tumor weight and volume of cervical cancer bearing mice were more reduced [1]. Clinical trial: N/A
- Properties
  - Alternative Name
    
    6-N-cyclohexyl-2-N-(4-morpholin-4-ylphenyl)-7H-purine-2,6-diamine
    
    CAS Number
    
    656820-32-5
    
    Molecular Formula
    
    C21H27N7O
    
    Molecular Weight
    
    393.49
    
    Appearance
    
    A solid
    
    Purity
    
    99.09%
    
    Solubility
    
    insoluble in H2O; ≥19.65 mg/mL in DMSO; ≥6.69 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5
    
    * For Research Use Only

Reversine

Reversine

Background

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