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Recombinant Human TTK (N-GST tag)

Recombinant Human TTK (N-GST tag)

Catalog Number:
E001278584APP
Mfr. No.:
Z500398
Price:
$672
  • Size:
    10 µg
    Quantity:
    Add to Cart:
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      • Overview

        • TTK is a serine/threonine kinase that has been implicated in the regulation of centrosome duplication and mitotic checkpoint response. Overexpressing of dominant-negative TTK in human cell lines prevents centrosome duplication while active TTK accelerates centrosome reduplication in an osteosarcoma cell line. Disruption of TTK function leads to a combination of severe mitotic abnormalities and failure in centrosome duplication. TTK is required for stabilization and activation of p53 during spindle disruption. TTK phoshorylates the N-terminal domain of p53 at Thr18, and this phosphorylation disrupts the interaction with MDM2 and abrogates MDM2-mediated p53 ubiquitination.

          Please contact us at for specific academic pricing.

      • Properties
        • Name
          ESK, PYT, MPS1, MPS1L1, FLJ38280
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          130.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

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