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Recombinant Human TTBK1 (N-GST tag)

Recombinant Human TTBK1 (N-GST tag)

Catalog Number:
E001278586APP
Mfr. No.:
Z500397
Price:
$672
  • Size:
    10 µg
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • TTBK1 or tau-tubulin kinase 1 is a recently discovered brain-specific protein kinase involved in tau phosphorylation at Alzheimer’s disease-related sites. Two single nucleotide polymorphisms have been observed in the TTBK1 gene and these may play an important role in the pathogenesis of sporadic late-onset Alzheimer's disease. TTBK1 levels are upregulated in brains of human Alzheimer' disease (AD) patients compared with age-matched non-AD controls. Overexpression of TTBK1 in transgenic mice leads to increased phosphorylation-related neurofilament aggregation which results in significant age-dependent memory impairment.

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      • Properties
        • Name
          BDTK; RP3-330M21.4
          Source
          Insect cells
          Type
          Recombinant Proteins
          Formulation
          50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
          Storage
          Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
          Molecular Weight
          96.0 kDa
          Class
          Active Kinases

          * For research use only. Not for diagnostic or therapeutic use.

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