Recombinant Human Prolactin, Fc tag

- Overview
  - The Recombinant Human Prolactin, Fc tag can be used for research in lactation, cultivated milk products, immune cells, mammary epithelial cells, and beyond.
    
    Key features
    Activity: Confirmed functionality using cell proliferation assays
    Uniqueness: Confirmed to be N-glycosylated
    Safety: Confirmed to be negative for mycoplasma and below threshold for endotoxin from Lot-to-Lot - suited for cell culture and preclinical applications
    Price: Product price that is lowest on the market, without compromising quality
    
    The Recombinant Human Prolactin product consists of Prolactin tagged with the Fc portion of human IgG at the C-terminal end. Fc-tagging is known to enhance stability, solubility and effector function while maintaining multiple ligands'activity on their cognate receptor.
    
    Comes as lyophilized powder. For research use only.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Human Prolactin, also known by its gene name PRL, is a hormone produced by the pituitary gland. It is primarily responsible for promoting lactation in the mammary glands, but it also has pleiotropic effects in both males and females. Prolactin typically exists in two forms: a glycosylated version and a non-glycosylated version with 23 kDa. Each prolactin molecule is believed to bind with two Prl-receptor molecules. In addition to its role in lactation, peripheral prolactin production is associated with breast and prostate cancer development, regulation of reproductive function, and immune system control. Recent research has suggested that PRL has cytoprotective effects on pancreatic islet cells and liver tissue, which could be crucial for the success of transplantation in clinical settings.
- Properties
  - Protein Name
    
    Mammotropin, Luteotropic hormone, Luteotropin, PRL
    
    Source
    
    Drosophila melanogaster
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Verified by SDS PAGE to be >90% pure
    
    Formulation
    
    Lyophilized protein from 0.22 μm filtered solution in 50 mM TrisHCl, 100 mM NaCl, pH 7.4
    
    Storage
    
    Store at 5±3°C upon receipt. For longer term storage, we recommend storage at < -70°C.
    
    Sequence
    
    This protein carries a human IgG Fc tag at the C-terminus with a protease cleavage site linking the protein with the tag. The protein has a calculated MW of 49.8 kDa. Full sequence available upon request.
    
    Endotoxin
    
    Below threshold of <1 EU/µg of hPrl.Fc
    
    Activity
    
    Determined by proliferation of NB2-11 cells (EC50 = 10-30 ng/ml)
    
    * For research use only. Not for diagnostic or therapeutic use.

Datasheet

MSDS

Documents

Performance Report - Future Fields Recombinant Human Prolactin (PRL-Fc)

Recombinant Human Prolactin, Fc tag

Recombinant Human Prolactin, Fc tag

Background

Documents

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