Recombinant Human Prion Protein

Recombinant Human Prion Protein

Catalog Number:
P001413743ABE
Mfr. No.:
Abe32-4498
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Size:
10 µg
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    • Overview

      • PRNP Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 229 amino acids (23-230a.a) and having a molecular mass of 25kDa. GOSR2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Prion protein (PRNP) is a ubiquitous membrane glycoprotein whose abnormal self-replicating, misfolded form is widely believed to cause several central nervous system disorders, together known as Transmissible Spongiform Encephalopathies (TSE). PRNP contains a highly unstable region of five tandem octapeptide repeat. Mutations in PRNP protein's repeat region as well as elsewhere have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru.

        Please contact us at for specific academic pricing.

    • Properties
      • Protein Name
        ASCR, CD230, CJD, GSS, MGC26679, prion, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, Major prion protein, PRNP.
        Source
        E. coli
        Type
        Recombinant Proteins
        Purification
        Greater than 90% as determined by SDS-PAGE.
        Formulation
        PRNP protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1M Urea and 10% glycerol.
        Storage
        Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

        * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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