Recombinant Human Polyglutamine Binding Protein 1

Recombinant Human Polyglutamine Binding Protein 1

Catalog Number:
P001413740ABE
Mfr. No.:
Abe32-4492
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Size:
20 µg
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    • Overview

      • PQBP1 Human Recombinant produced in E. coli is a single polypeptide chain containing 289 amino acids (1-265) and having a molecular mass of 33.0kDa. PQBP1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. PQBP1 is a transcription repressor which is connected to polyglutamine tract-containing transcription regulators and connective genes for neurodegenerative disorders. PQBP1 is restricts to the nucleus and can be found in neurons all over the brain, with high levels in hippocampus, olfactory bulb and cerebellar cortex. PQBP1 holds a WWP/WW domain that binds proline-rich motifs and a C2 domain which is able to stimulate Ca2+-dependent phospholipid signaling.

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    • Properties
      • Protein Name
        Golyglutamine binding protein 1, Polyglutamine tract-binding protein 1, 38kDa nuclear protein containing a WW domain, mental retardation X-linked 55, Sutherland-Haan X-linked mental retardation syndrome, Npw38, MRXS3, MRX55, MRXS8, RENS1, SHS.
        Source
        E. coli
        Type
        Recombinant Proteins
        Purification
        Greater than 95% as determined by SDS-PAGE.
        Formulation
        The PQBP1 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 100mM NaCl and 20% glycerol.
        Storage
        Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

        * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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