Recombinant Human Insulin-like Growth Factor Binding Protein 3/IGFBP3 (C-hFc)

Recombinant Human Insulin-like Growth Factor Binding Protein 3/IGFBP3 (C-hFc)

Catalog Number:
P001412814ABE
Mfr. No.:
Abe32-9088
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      • Overview
        • Insulin-like growth factor-binding protein 3 (IGFBP3) is a member of IGF binding protein superfamily. IGF binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth-promoting effects of the IGFs on cell culture. IGFBP3 is expressed by most tissues and the expression levels are higher during development. It is up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, EGF and phorbol esters. IGFBP3 is the most abundant IGF binding protein in human serum and has been shown to be a growth inhibitory, apoptosis-inducing molecule, capable of acting via IGF-dependent and IGF-independent mechanisms. Several clinical studies have shown that individuals with IGFBP3 levels in the upper range of normal may have a decreased risk for certain common cancers

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      • Properties
        • Protein Name
          acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; growth hormone-dependent binding protein; IBP-3; IBP3BP-53; IGF-binding protein 3; IGFBP3; IGFBP-3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3
          Source
          HEK293 cells
          Type
          Recombinant Proteins
          Formulation
          Lyophilized from a 0.2 um filtered solution of PBS, pH7.4

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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