Name: Q14
Price: 301.00 USD

- Overview
  - USP30 inhibitor.
    Q14 is a peptide derived from the transmembrane domain of the mitochondrial anchored deubiquitinating enzyme USP30 (ubiquitin specific peptidase 30). Q14 can easily cross the cell membrane, bind to mitochondrial anchored USP30 directly, degrade outer mitochondrial membrane (OMM) proteins, promote mitochondrial fission, and trigger mitophagy. Q14 increases mitophagy through two distinct mechanisms, autoinhibition of USP30, and accelerated autophagosome formation through the LC3-interacting region (LIR) of Q14, synergistically enhancing mitophagy. USP30 antagonises PRKN/parkin-mediated mitophagy, making it a potential target for treating Parkinsons disease.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Peptides
    
    Alternative Name
    
    Q14 peptide
    
    Molecular Formula
    
    C99H166N32O22
    
    Molecular Weight
    
    2156.6
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Gly-Ile-Tyr-Val-Ile-Trp-Gly-Pro-Ile-Thr-Glu-Arg-Lys-Lys-Arg-Arg-Lys-Gly-NH2,GIYVIWGPITERKKRRKG-NH2
    Modification: C terminal amide
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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