Pyrrolidino PAF C-16

- Overview
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    Background
    
    Pyrrolidino PAF C-16 is a synthetic analog of PAF C-16 with hypotensive action [1][2]. Platelet activating factor (PAF; C16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF have potent hypotensive activity. C16-PAF was about three times more potent than C18-PAF in the activity of releasing serotonin [1][2]. Pyrrolidino PAF C-16, a synthetic analog of PAF C-16, is a potent mediator of PAF-like activities, including hypotension and platelet aggregation [1][2]. In male Wistar rats, Pyrrolidino PAF C-16 dose-dependently decreased blood pressure and the duration of the hypotension was also dose-dependent. Pyrrolidino PAF C-16 was 3-10 times more potent than natural PAF in the hypotensive activity [1][2].
    
    [1]. Shigenobu K, Masuda Y, Tanaka Y, et al. Platelet activating factor analogues: lack of correlation between their activities to produce hypotension and endothelium-mediated vasodilation. J Pharmacobiodyn. 1985 Feb;8(2):128-33.
    [2]. Kasuya Y, Masuda Y, Shigenobu K. Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF. Can J Physiol Pharmacol. 1984 Apr;62(4):457-9.
- Properties
  - Categories
    
    potent mediator of PAF-like activitie
    
    Alternative Name
    
    1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphoryl-N-methyl-pyrrolidinium ethanol
    
    CAS Number
    
    91021-63-5
    
    Molecular Formula
    
    C28H56NO7P
    
    Molecular Weight
    
    549.7
    
    Appearance
    
    A lyophilized powder
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤25mg/ml in PBS
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCCCCCCCCCCCCCCCOC[[email protected]@H](OC(C)=O)COP(OCC[N+]1(C)CCCC1)([O-])=O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Pyrrolidino PAF C-16

Background

Documents

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