N-Acetylserotonin

- Overview
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    Background
    
    N-Acetylserotonin is an agonist at the melatonin receptors MT1, MT2, and MT3. A melatonin receptor is a G protein-coupled receptor binding melatonin. Three types of melatonin receptor have been identified. The MT1 and MT2 receptor subtypes are in humans and other mammals, whereas an additional melatonin receptor subtype MT3 has been identified in amphibia and birds.In vitro: N-Acetylserotonin, a precursor of melatonin, was acetylated from serotonin by arylalkylamine Nacetyltransferase (AANAT). N-Acetylserotonin was found to be able to swiftly activate TrkB in a circadian manner. N-Acetylserotonin also exhibited antidepressant effect in a TrkB-dependent manner. In additioin, N-acetylserotonin could rapidly activate TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner. Moreover, N-acetylserotonin, but not melatonin, showed a robust antidepressant-like behavioral effect in a TrkB-dependent way [1].In vivo: Animal study found that in BDNF knockout mice the administration of N-acetylserotonin could activate TrkB. Moreover, the endogenous TrkB was activated in wild-type C3H/f+/+ mice but not in AANAT-mutated C57BL/6J mice, in a circadian rhythm. In addition, TrkB activation was found to be high at night in the dark and low during the day [1].Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Categories
    
    an agonist at the melatonin receptors MT1, MT2, and MT3
    
    Alternative Name
    
    N-Acetyl-5-hydroxytryptamine,NAS; N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-acetamide
    
    CAS Number
    
    1210-83-9
    
    Molecular Formula
    
    C12H14N2O2
    
    Molecular Weight
    
    218.3
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥11.5 mg/mL in EtOH; ≥33.65 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    OC1=CC=C(NC=C2CCNC(C)=O)C2=C1
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

N-Acetylserotonin

Background

Documents

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