Butenoyl PAF

- Overview
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    Background
    
    Butenoyl PAF is a PAF receptor agonist [1].Platelet activating factor (PAF), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF play important roles in a variety of pathophysiological states including acute allergy, inflammation, asthma, gastrointestinal ulceration, and toxic shock [1][2]. Butanoyl-PAF and Butenoyl PAF are both products of the oxidative decomposition of 2-arachidonoyl phospholipids. Although Butenoyl PAF is 10-fold less potent than PAF as a PAF receptor agonist and ligand, it is 100-fold more abundant in oxidized LDL than PAF. Therefore, oxidation products of LDL phospholipids were physiologically relevant bioactive PAF-like molecules [1].
    
    [1]. Marathe GK, Davies SS, Harrison KA, et al. Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. J Biol Chem. 1999 Oct 1;274(40):28395-404.
    [2]. Davies SS, Pontsler AV, Marathe GK, et al. Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists. J Biol Chem. 2001 May 11;276(19):16015-23.
- Properties
  - Categories
    
    PAF receptor agonist
    
    Alternative Name
    
    1-O-hexadecyl-2-O-(2E-butenoyl)-sn-glyceryl-3-phosphocholine
    
    CAS Number
    
    474944-25-7
    
    Molecular Formula
    
    C28H56NO7P
    
    Molecular Weight
    
    549.7
    
    Appearance
    
    A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
    
    Purity
    
    98.00%
    
    Solubility
    
    ≤0.5mg/ml in DMSO;10mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C(/C=C/C)O[[email protected]@H](COP([O-])(OCC[N+](C)(C)C)=O)COCCCCCCCCCCCCCCCC
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Butenoyl PAF

Background

Documents

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