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Pyridoxine Hydrochloride

Pyridoxine Hydrochloride

Catalog Number:

MAR1341450TOK

Mfr. No.:

TOK-P024

Price:

$148

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- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Pyridoxine serves as a precursor of pyridoxal-phosphate (PLP), a coenzyme for amino acid and nucleic acid metabolism and neurotransmitter synthesis.
- Properties
  - CAS Number
    
    58-56-0
    
    Molecular Formula
    
    C8H11NO3 · HCl
    
    Molecular Weight
    
    205.64
    
    Appearance
    
    White or almost white crystalline powder
    
    Solubility
    
    Soluble in water and DMSO. Insoluble in water.
    
    Other Properties
    
    Source: Synthetic
    
    Storage
    
    2-8 °C
    
    * For research use only
- Applications
  - Application Description
    
    Eukaryotic Cell Culture Applications: Pyridoxine was used in a stably transformed Chinese Hamster Ovary (CHO) cells expressing normal and mutant forms of AGT (alanine:glyoxylate aminotransferase) in the study of primary hyperoxaluria type 1 (PH1), a rare heriditary calcium oxalate kidney stone disease caused by AGT deficiency. Researchers showed Pyridoxine increases the expression, activity and import of the most common mistargeted mutant forms of AGT. This demonstrates that Pyridoxine, which is metabolised to pyridoxal phosphate (the essential cofactor of AGT) acts as a prosthetic group and chaperone. This should help to aid pharmacological treatments of PH1 (Fargue et al, 2013).

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