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Overview
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Background
PSB 1114 is a potent and selective agonist of P2Y2 receptor with EC50 value of 0.134 μM [1]. P2Y2 receptor is a purinergic G protein-coupled receptor and is activated by ATP and UTP. P2Y2 receptor is a potential target for treatment of cystic fibrosis. PSB 1114 is a potent and selective P2Y2 receptor agonist. PSB 1114 activated P2Y2, P2Y4 and P2Y6 with EC50 values of 0.134, 9.3 and 7.0 μM respectively and exhibited >60-fold selectivity versus P2Y6 and P2Y4 receptors [1].
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- Properties
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Overview