prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens]

- Overview
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    Background
    
    prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens], (C26H41N9O9), a peptide with the sequence H2N-Ala-Thr-Gly-Gly-Tyr-Arg-OH, MW= 623.66. Prostate apoptosis response-4 (Par-4), is a human gene coding for a tumor-suppressor protein that induces apoptosis in cancer cells, but not in normal cells.The tumor suppressor PAR-4 represses and activates transcription. The protein encoded by this gene is a PAR-4-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of PAR-4. This protein is specifically upregulated during apoptosis of prostate cells(1).The active domain of the Par-4 protein has been found to confer cancer resistance in transgenic mice without compromising normal viability or aging, and may have therapeutic significance(2).
    
    1. Johnstone, R W; See R H, Sells S F, Wang J, Muthukkumar S, Englert C, Haber D A, Licht J D, Sugrue S P, Roberts T, Rangnekar V M, Shi Y (Dec. 1996). "A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1". Mol. Cell. Biol. (UNITED STATES) 16 (12): 6945–56.
    2. Zhao Y, Burikhanov R, Qiu S, Lele SM, JenningsCD, Bondada S, Spear B, Rangnekar VM (2007). "Cancer resistance in transgenic mice expressing the SAC module of Par-4". Cancer Res. 67 (19): 9276–85.
- Properties
  - Categories
    
    Transcriptional repressor
    
    Alternative Name
    
    H2N-Ala-Thr-Gly-Gly-Tyr-Arg-OH
    
    Molecular Formula
    
    C26H41N9O9
    
    Molecular Weight
    
    623.66
    
    Appearance
    
    A solid
    
    Purity
    
    99.46%
    
    Solubility
    
    ≥62.3 mg/mL in DMSO; ≥22.28 mg/mL in EtOH with ultrasonic; ≥59.8 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC(C(NC(C(O)C)C(NCC(NCC(NC(CC1=CC=C(O)C=C1)C(NC(CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)N
    
    * For Research Use Only