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Overview
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A cell-permeable pan deubiquitinating enzyme inhibitor that is known to inhibit ATXN3, BAP1, JOSD2, OTUD5, UCH-L1, UCH-L3, UCH-L5/UCH37, USP1, 2, 4, 5, 7, 8, 9X, 10, 14, 15, 16, 19, 20, 22, 24, 28, 47, 48, VCIP135, YOD1, as well as deISGylase PLpro, deNEDDylase DEN1, and deSUMOlyase SENP6. PR-619 inhibits many deubiquitinating enzymes in the 5-20µM range. Treating cells with PR-619 results in the accumulation of both ubiquitin and sumo-conjugated proteins.
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- Properties
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Overview
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