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PJ34 hydrochloride

PJ34 hydrochloride

Catalog Number:

L002369066APE

Mfr. No.:

APE-A4159

Price:

$204

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- Overview
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    Background
    
    PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. Unlike other PARP inhibitors (such as 3-AB), PJ34 does not possess any antioxidant properties but exhibits 10,000 times greater PARP inhibition than 3-AB (EC50 = 200 μM). PJ34 has been found to have neuro-protective effects and enhance the chemotherapeutic effects in several tumor types. Study results have shown that PJ34 inhibits peroxynitrite-induced cell necrosis with EC50 value of 20 nM and dose-dependently suppresses the growth of HepG2 cells.
- Properties
  - Alternative Name
    
    PJ 34 Hydrochloride; 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;hydrochloride
    
    CAS Number
    
    344458-15-7
    
    Molecular Formula
    
    C17H17N3O2·HCl
    
    Molecular Weight
    
    331.8
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥16.6 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl
    
    * For Research Use Only

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