Name: 3-aminobenzamide
Price: 180.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    3-Aminobenzamide (PARP-IN-1) is a potent inhibitor of PARP with IC50 of appr 50 nM in CHO cells, and acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.
    3-Aminobenzamide (PARP-IN-1) (>1 μM) causes more than 95% inhibition of PARP activity without significant cellular toxicity. 3-Aminobenzamide significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM H2O2 [1].
    In a db/db (Leprdb/db) mouse model, 3-Aminobenzamide ameliorates diabetes-induced albumin excretion and mesangial expansion, and decreases diabetes-induced podocyte depletion [2].
    [1]. Radovits T, et al. Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. Eur J Pharmacol. 2007 Jun 14;564(1-3):158-66.
    [2]. Szabo C, et al. Poly (ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes. 2006 Nov;55(11):3004-12.
- Properties
  - Alternative Name
    
    PARP-IN-1; 3-aminobenzamide
    
    CAS Number
    
    3544-24-9
    
    Molecular Formula
    
    C7H8N2O
    
    Molecular Weight
    
    136.15
    
    Appearance
    
    A solid
    
    Purity
    
    99.92%
    
    Solubility
    
    ≥23.45 mg/mL in H2O with ultrasonic; ≥48.1 mg/mL in EtOH with ultrasonic; ≥7.35 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Grunewald ME, Chen Y, et al. "The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression." PLoS Pathog. 2019 May 16;15(5):e1007756. PMID:31095648
    2. Waldman M, Nudelman V, et al. "PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis." Exp Cell Res. 2018 Oct 23. pii: S0014-4827(18)31064-4. PMID:30359575

3-aminobenzamide

3-aminobenzamide

Background

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