pEGFP-HMGB1 plasmid

- Overview
  - Plasmid pEGFP-HMGB1 was obtained by inserting the coding sequence for the rat HMGB1 into pEGFP-N1 (Clontech) using the EcoRi and SacII restriction sites (Scaffidi et al. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002, 418: 191-5). It expresses HMGB1-GFP, which is rat HMGB1 (at the N terminus) fused to GFP (at the C terminus). This protein is fully functional and is functionally equivalent to unmodified HMGB1 (Pallier et al. Association of chromatin proteins HMGB1 and HMGB2 with mitotic chromosomes. Mol Biol Cell 2003, 14: 3414-26).
    
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- Properties
  - Categories
    
    Plasmids
    
    * This product is intended for research only, and cannot be used on humans.
- Reference
  - The Regulatory Role of Nuclear Respiratory Factor 1 in Bladder Cancer Cells
    CUL4A-mediated ZEB1/microRNA-340-5p/HMGB1 axis promotes the development of osteoporosis
    Leukoreduced PRP enhanced proliferation and ECM production yet inhibited senescence, inflammation, and multi-differentiation potential of AFSCs by downregulating HMGB1
    HSF1 enhances the attenuation of exosomes from mesenchymal stem cells to hemorrhagic shock induced lung injury by altering the protein profile of exosomes
    The Role of Box A of HMGB1 in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-aging Therapy
    Determination of the Impact of High-Intensity Pulsed Electromagnetic Fields on the Release of Damage-Associated Molecular Pattern Molecules
    Afzelin induces immunogenic cell death against lung cancer by targeting NQO2
    Evidence for SIRT1 Mediated HMGB1 Release From Kidney Cells in the Early Stages of Hemorrhagic Shock
    The Anti-inflammatory Effects of HMGB1 Blockades in a Mouse Model of Cutaneous Vasculitis
    Nonoxid-HMGB1 Attenuates Cognitive Impairment After Traumatic Brain Injury in Rats