Name: PDpep1.3
Price: Inquiry

- Overview
  - ?-Synuclein-CHMP2B interaction disruptor.
    PDpep1.3 is a peptide optimised from a hit from a high-throughput screen to identify protein-protein interaction inhibitors that reduce ?-synuclein oligomer levels and their associated cytotoxicity. PDpep1.3 disrupts the direct interaction between the C-terminal region of ?-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B), a component of the endosomal sorting complex required for transport-III (ESCRT-III). ?-Synuclein impedes endolysosomal activity via this interaction with CHMP2B, inhibiting its own degradation, and blockade of it with PDpep1.3 restores endolysosomal function and decreases ?-synuclein levels in human cells. In vivo, PDpep1.3 protects dopaminergic neurons from ?-synuclein-mediated degeneration in Parkinson’s disease models in rats.
    
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- Properties
  - Categories
    
    Peptides
    
    Molecular Formula
    
    C59H101N17O22
    
    Molecular Weight
    
    1399.73
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Sequence: H-Asp-Glu-Glu-Ile-Glu-Arg-Gln-Leu-Lys-Ala-Leu-Gly-OH,DEEIERQLKALG
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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