PC-766B

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    PC-766B is a macrolide antibiotic existed in anactinomycete strain SC-4710.
    PC-766B was active against Gram-positive bacteria, and some fungi and yeasts, yet inactive against Gram-negative bacteria. PC-766B exhibited potent cytotoxicity against murine tumor cell lines in vitro. The IC50 values against P388 leukemia and B16 melanoma were 0.1 and 0.5 ng/ml, respectively [1]. Intraperitoneal administration of PC-766B (0.25mg/kg/day) showed in vivo antitumor activity against P388 leukemia. PC-766B showed a weak inhibitory activity against Na+, K+-ATPase [1].
    
    [1] KUMAGAI K, TAYA K, FUKUI A, et al. PC-766B, A NEW MACROLIDE ANTIBIOTIC PRODUCED BY Nocardia brasiliensis[J]. The Journal of antibiotics, 1993, 46(6): 972-978.
- Properties
  - Categories
    
    macrolide antibiotic
    
    Alternative Name
    
    Antibiotic PC-766B; 16-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[(2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]tetrahydro-2-hydroxy-5-methyl-6-[(1E,3E)-1,3-pentadien-1-yl]-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-(3Z,5E,7R,8S,9S,11E,13E,15S,16
    
    CAS Number
    
    108375-77-5
    
    Molecular Formula
    
    C43H68O12
    
    Molecular Weight
    
    777.0
    
    Appearance
    
    A solid
    
    Purity
    
    Purity ≥ 95.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C1O[[email protected]]([[email protected]@H](C)[[email protected]@H](O)[[email protected]@H]([[email protected]@]2(O)C[[email protected]@H](O[[email protected]]3C[[email protected]]([[email protected]@H]([[email protected]@H](C)O3)O)O)[[email protected]](C)[[email protected]@H](/C=C/C=C/C)O2)C)[[email protected]@H](OC)/C=C/C=C(C)/C[[email protected]](C)[[email protected]](O)[[email protected]](C)/C=C(C)/C=C1\OC
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Datasheet

PC-766B

Background

Documents

We Also Recommend

4-(n-nonyl) Benzeneboronic Acid

ML351

Quinestrol