Name: 4-(n-nonyl) Benzeneboronic Acid
Price: 241.00 USD

- Overview
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    Background
    
    IC50: 9.1 nM4-(n-nonyl) Benzeneboronic acid is a dual FAAH inhibitor.Fatty acid amide hydrolase (FAAH), a membrane-bound enzyme of the endocannabinoid system, has been identified as a potential target for therapeutic agents in the treatment of various medical conditions, such as inflammation and pain. FAAH and monoglyceride lipase (MGL) have been reported to be the primary enzyme responsible for the hydrolysis of endocannabinoid N-arachidonoyl ethanolamide (AEA), which is a key lipid messenger in the brain and periphery. In vitro: 4-(n-Nonyl) benzeneboronic acid was synthezed as a potent inhibitor of FAAH, with an IC50 of 9.1 nM. 4-(n-Nonyl) benzeneboronic acid was also found to be able to inhibit MAGL, which could hydrolyze 2-arachidonoyl glycerol, but at around 1000-fold higher concentration. Moreover, it was found that as the most potent para-substituted compound, 4-(n-Nonyl) benzeneboronic acid showed rather high pKa of 9.1. In addition, the molecular docking was utilized to gain insight on the FAAH binding mode of 4-(n-Nonyl) benzeneboronic acid and a putative binding mode was observed [1].In vivo: Up to now, there is no animal in vivo data reported.Clinical trial: So far, no clinical study has been conducted.
- Properties
  - Alternative Name
    
    B-(4-nonylphenyl)-boronic acid
    
    CAS Number
    
    256383-45-6
    
    Molecular Formula
    
    C15H25BO2
    
    Molecular Weight
    
    248.2
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥11.75 mg/mL in DMSO; ≥25.1 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

4-(n-nonyl) Benzeneboronic Acid

4-(n-nonyl) Benzeneboronic Acid

Background

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