pAAVone-AAVrh.74-CMV-mCherry

pAAVone-AAVrh.74-CMV-mCherry is a plasmid used to produce AAVrh.74-CMV-mCherry using novel AAVone production system. It integrates all the AAV production necessary components, including Ad helper genes (E2A, E4orf6 and VA RNA), AAV helper genes (Rep and AAVrh.74 Cap), and a single-strand AAV-CMV-mCherry genome. AAVrh.74-CMV-mCherry viruses can be simply and efficiently produced by transfection of this single-into host cells, such us HEK 293 and HEK 293T. AAVrh.74 is a recombinant adeno-associated virus (AAV) serotype derived from rhesus monkeys. It has gained prominence for its ability to efficiently transduce muscle tissue, making it particularly suitable for gene therapy applications targeting muscle disorders such as Duchenne muscular dystrophy (DMD). AAVrh.74 has been shown to have higher transduction efficiency in skeletal and cardiac muscles compared to other AAV serotypes, such as AAV9, and is being used in clinical trials for its potential to deliver therapeutic genes effectively.

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