Open tTGTM

- Overview
  - Human tissue transglutaminase recombinantly produced in insect cells, conjugated with a specific inhibitor in order to stabilize the open conformation. Thereby new epitopes become accessible.
    
    Please contact us at for specific academic pricing.
    
    Background
    
    Human tissue transglutaminase recombinantly produced in insect cells, conjugated with a specific inhibitor in order to stabilize the open conformation. Thereby new epitopes become accessible.
- Properties
  - Type
    
    Recombinant Proteins
    
    Purification
    
    > 95 % by SDS-PAGE under reducing conditions
    
    Storage
    
    Store working aliquots at ≤ - 20°C. Avoid repeated freeze-thaw cycles.The product is shipped on dry ice. Upon receipt, store immediately at ≤ -20°C.
    
    Note
    
    Intended for research use only, not for use in human or therapeutic applications. Usage in celiac disease diagnostic products may require a license for European Patent 0912898 and US Patent US 8,808,980 B2.
    
    Molecular Weight
    
    78 kDa (Val224-allele, Kanchan et al., Biochem. J. 2013, 455:261–72)
    
    Class
    
    Human Transglutaminase 2
- Applications
  - Application Description
    
    Open tTGTM may be used for immunoprecipitation and detection of autoantibodies in body fluid samples from patients suffering from autoimmune diseases like psoriasis or gluten sensitive enteropathy.
- Reference
  - Lortat-Jacob H. et al., J Biol Chem. 2012: 18005–18017
    Lindfors K. et al., J Clin Immunol. 2011: 436-42
    Pallav K. et al., Dig Liver Dis. 2012: 375-8
    Giannetto et al. Biosens Bioelectron. 2014, 62:325-30
    Protein Data Bank (PDB) entry: 3S3P

Datasheet

MSDS

Open tTGTM

Background

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