Octyl b-D-glucopyranoside - Amerigo Scientific

- Overview
  - Octyl β-D-glucopyranoside is an alkylglycoside non-ionic detergent and is one of the most commonly used in membrane protein isolation. As it is uncharged, it is unlikely to cause protein denaturation or refolding issues, allowing for the isolation of intact macromolecular complexes without affecting protein-protein interactions. Octyl β-D-glucopyranoside, also known as octylglucoside or OG, forms small, uniformed micelles and has an aggregation number of between 27-100. It is readily dialyzable from membrane protein preparations due to its high Critical Micelle Concentration (CMC) of 18-20mM. Octyl β-D-glucopyranoside has similar uses and properties to that of another frequently used surfactant, Octyl β-D-thioglucopyranoside.
    
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- Properties
  - Alternative Name
    
    n-Octylglucoside;1-O-Octyl b-D-glucopyranoside;OG;Caprylyl glucoside
    
    CAS Number
    
    29836-26-8
    
    Molecular Formula
    
    C14H28O6
    
    Molecular Weight
    
    292.37 g/mol
    
    MDL Number
    
    MFCD00063288
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Lorber et al (1990). Purification of octyl beta-D-glucopyranoside and re-estimation of its micellar size. Biochimica et Biophysica Acta 1023(2):254-65.
    deGrip et al (1979). Synthesis and properties of alkylglucosides with mild detergent action: improved synthesis and purification of β-1-octyl-, -nonyl-, and -decyl-glucose. Synthesis of β-1-undecylglucose and β-1-dodecylmaltose. Chemistry and Physics of Lipids 23(4):321-335.
    Morandat et al (2006). Solubilization of supported lipid membranes by octyl glucoside observed by time-lapse atomic force microscopy. Colloids and Surfaces B: Biointerfaces. 55(2):179-184.

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